Lipids

`->` Fat and its derivatives are combinaly known as lipid .

`->` Lipid term coined by Bloor.

`->` Compounds of `C, H, O` but the ratio of Hydrogen and Oxygen is not `2:1`. The amount of oxygen is considerably very less.

`->` Lipids are insoluble in water and soluble in organic solvents like acetones, chloroform, benzene, hot alcohoL ether etc.

`->`Lipids occur in protoplasm as minute globules .

`->` Lipids do not form polymer .

`->` Lipids provide more than double energy as compare to carbohydrate .

`->`In animals, fat present in subcutaneous layer and working as food reservoir and shock-absorber. Lipid requires less space for storage as compare to carbohydrate because lipid molecule is hydrophobic and condense.

`->` Animals store maximum amount of food in the form of lipid .

`->` Lipid provides maximum amount of metabolic water as compare to carbohydrate and protein on oxidation .

`->` Lipids are not strictly macromolecules.

`->`Lipids are called fats and oils on the basis of melting point. Oils have lower melting point and fats have higher melting point.

`->` Some lipid also have phosphorus like lecithin .

(A) Simple Lipid or Neutral Fats :-

`-> ` These are esters of long chain fatty acids and alcohol. In majority of simple lipids, the alcohol is a trihydroxy
sugar alcohol i.e. glycerol.

`-> ` Three molecules of fatty acid linked with one molecule of glycerol. The linkage is called "ester bond" . Such type
of lipids called Triglycerides. Three molecules of water are released during formation of triglycerides (dehydra -
tion synthesis)

`-> ` Glycerol is also known as lrihydroxy propane .

`-> ` Similar or different fatty acids pariicipate in the composition of a fat molecule. Simple lipids contain two types
of fatty acids.

`-> ` Simple lipids contain two types of fatty acids.

Simple lipids contain two types of fatty acids.

Waxes are monoglycerides with only one molecule of fatty acid attached to a monohydroxy alcohol.

Waxes :- are monoglycerides with only one molecule of fatly acid dltached lo a lcmg chainmonohydroxy alcohol. Waxes are more resistant to hydrolysis as compared to 1riglycerides. Waxes have an important role in protection. They form water insoluble coatings on hair and skin in animals and stem, leaves and fruits of plants.

e.g.
Bees Wax (Hexacosyl palmitate)

Carnauba (Myricyl cerotate) which occurs on leaves, stem and fruits.

Spermaceti In skull of whale and Dolphin.

Cerumen or ear wax - occurs in external auditory meatus

lanoline or cholesterol ester- occurs in blood, sebum and gonadial duels as lubricating agent
It is also obtained from wool of sheep.

(B) Conjugated or Compound Lipids :-

(1) Phospholipids or phosphatide or phospholipins :-

2 Molecules of fatty acid + c;Jycerol + `H_(3)PO_(4)` + Nitrogenous compound. Phospholipids are most abun·
dant type of lipids in protoplasm.

Phospholipids have both hydrophilic polar end (`H_(3)PO_( 4)` and nitrogenous compound) and hydrophobic non
polar end (fatty acids). Such molecules are called amphipathic. Due to this property, phospholipids form
bimolecular layer in cell membrane.

Some biologically important phospholipids are as following :

(a) Lecithin or Phosphatidyl choline

`->` Nitrogenous compound in lecithin is choline

`->` Lecithin occurs in egg yolk, oil seeds and blood.

`->` In blood lecithin functions as carrier molecule. It helps in transportation of other lipid.

(b) Cephalin-Similar to lecithin but the nitrogenous compound is ethanolamine, cephalin occurs in nervous tissue, egg yolk and blood platelets.

(c) Sphingolipid.s or sphingomyelins similar to lecithin but in place of Blycerol it contains an amino alcohol sphingosine.

Sphingolipids occur in myelin- sheath of nerves, other examples of phospholipid are phosphatidyl
serine, phosphatidyl inositol, plasmologens.

(2) Glycolipid :- 2 fatty acid + sphingosine + galactose
eg. Cerebroiside which occurs in white matter of brain

Gangliosides -These occur in nerve ganglia and spleen. These also contain N-acetyl neuromink
acid and glucose beside other compounds.

(3) Derived Lipids ~- Lipid derived from simple or conjugated lipid .Derived lipids are complex in struc
ture. They are insoluble in water and soluble in organic solvents

(1) Steroids :- Steroids exhibit tetracyclic structure called "Cydo pentano perhydrophenanthrene nucleus" On the basis of functional group, steroids are of two types-

(a) Sterols:- Alcoholic steroids e.g. cholesterol- Cholesterol abundantly occurs in brain, nervous tissue , Adrenal gland and skin. Cholesterol is a parent steroid. Several other biologically important steroids are derived from cholesterol 7 dehydrocholesterol which occurs in skin is a provitamin. On exposure to ultraviolet radiation, it transforms in cholecalciferol i. e vitamin D

`->` Cholesterol is also called "most decorated micromolecule in biology".

Ergosterol :-It occurs in oil seed , fungi like ergot and yeast . Ergosterol is precursor of another form of Vitamin D-Ergocalciferol.

Coprosterol :-Occurs in faecal matter. It forms by decomposition of cholesterol by colon bacteria

Bile acid:- Bile Juice contains different types of steroid acids. e. g. cholic acid. Lithocholic acid etc.
They help in emulsification of fats.

(b) Sterones :- Ketonic steroids, for e. g. sex hormones, Adreno corticoids , ecdyson hormone of insects,Diosgenin obtained from yam plant (Dioscorea), is used in manufacture of antifertility pills.

(2) Chromolipid = It is also called terpene.

`->` Most complex lipid in protoplasm.

`->` Chromolipids composed of repeated isoprene units

Example : Carotenoids, vitamin `A, E, K`, Natural Hubber (Polyterpene)

 
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