Biology HUMAN HEALTH AND DISEASE

Cancer

Cancer is one of the most dreaded diseases of human beings and is a major cause of death all over the globe. More than a million Indians suffer from cancer and a large number of them die from it annually. The mechanisms that underlie development of cancer or oncogenic transformation of cells, its treatment and control have been some of the most intense areas of research in biology and medicine.

- Uncontrolled, Abnormal and excessive mitotic division of cells is called cancer (Crab = cancer).
- Study of cancer is called oncology.
- This abnormal and undifferentiated cells are called cancerous cells.

TUMOUR OR NEOPLASM (New growth) :

Types of Tumours-
(a) Benign Tumour : Capsulated, localised to the site of origin & does not spread to another parts of body, it is non-
metastatic, non-malignant, non-cancerous, Non invasive.
eg :
Bone tumour - Osteoma
Muscle tumour - Myoma
Lymph node tumour - Lymphoma

(b) Malignant Tumour (Malignant = Harmful) : Some of the cancerous cells detach from their origin place and spread to other parts of body by blood and lymph. Now the cancerous cells form fresh colonies there. This is called metastasis or sec. growth. This type of tumour is called metastatic or cancerous tumour. It is Invasive tumour.
e.g. All malignant tumour are called cancers.

In our body, cell growth and differentiation is highly controlled and regulated. In cancer cells, there is breakdown of these regulatory mechanisms. Normal cells show a property called contact inhibition by virtue of which contact with other cells inhibits their uncontrolled growth. Cancer cells appears to have lost his property. As a result of this, cancerous cells just continue to divide giving rise to masses of cells called tumors.

Tumors are of two types : benign and malignant. Benign tumors normally remain confined to their original location and do not
spread to other parts of the body and cause little damage. The malignant tumors, on the other hand are a mass of proliferating cells called neoplastic or tumor cells. These cells grow very rapidly, invading and damaging the surrounding normal tissues. As these cells actively divide and grow they also starve the normal cells by competing for vital nutreients. Cells sloughed from such tumors reach distant sites through blood, and wherever they got lodged in the body, they start a new tumor there. This roperty called metastasis is the most feared property of malignant tumors.

 
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