Biology HUMAN REPRODUCTION

Placenta.

Placenta is defined as a temporary intimate mechanical and physiological connection between foetal and maternal tissues for the nutrition, respiration and excretion of the foetus.

# Structure : Human placenta consist of chorion only. Hence, it is called a chorionic placenta. Allantois remains small. The allantoic blood vessels, however, extend to vascularize it. A large number of branching villi from the vascular chorion penetrate the corresponding pits, the crypts, formed in the uterine wall. The latter becomes very thick and highly vascular to receive the villi. The intimate connection established between the foetal membrane and the uterine wall is known as the placenta. The placenta has two parts : the part contributed by the foetus, i.e., chorionic villi, is called the foetal placenta; and the part shared by the mother, i.e., part of uterine wall, is termed the maternal placenta. The chorionic villi receive blood from the embryo by umbilical artery and return it by umbilical vein. These blood vessels are derived from the allantois and run between the foetus and the uterine wall in the tough umbilical cord covered with cells derived from the amnion and chorion. The choroinic villi come to lie in uterine lacunae that receive blood from the uterine arteriole and return it by uterine venule. The cells forming the wall of chorionic villi bear microvilli which increase their surface area for quick and adequate exchange of materials by diffusion, active transport and pinocytosis.

The placenta is fully formed by the end of the third month and it lasts throughout pregnancy. When complete, it is a reddish – brown disc. In the placenta, the foetal blood comes very close to the maternal blood, and this permits the exchange of materials between the two. Food (glucose, amino acids, simple proteins, lipids), water, mineral salts, vitamins, hormones, antibodies and oxygen pass from the maternal blood into the foetal blood, and foetal metabolic wastes, such as carbon dioxide and urea, also water and hormones, pass into the maternal blood. The placenta, thus, serves as the nutritive, respiratory and excretory organ of the foetus. The continuous uptake of oxygen by foetal blood is ensured by the difference in affinity for oxygen between foetal and maternal haemoglobin.
The maternal and foetal blood are not in direct contact in the placenta, because (i) the two may be incompatible; (ii) the pressure of maternal blood is far too high for the foetal blood vessels; and (iii) there must be a check on the passage of harmful materials (blood proteins, germs) into the foetal blood.

Functions

1) Placenta helps in the nutrition of the embryo as the nutrients like amino acids, monosugars, vitamins, etc. pass from the maternal blood into foetal blood through placenta.
(2) It also helps in respiration of the embryo as O2 of the maternal blood and CO2 of the foetal blood diffuse through placenta into the foetal blood and maternal blood respectively.
(3) It also helps excretion of the embryo as nitrogenous wastes of foetal blood like urea pass into maternal blood through placenta.
(4) It also acts as an endocrine gland as it secretes certain hormones like estrogens, progesterone and human chorionic gonadorophin (HCG). HCG maintains the corpus luteum for the continued secretion of progesterone to maintain the pregnancy. At the end of gestation period, it also secretes relaxin which helps in softening of pubic symphysis and child birth. It also secrete small amounts of chorionic thyrotrophin, chorionic corticotropin and chorionic somatomammotropin.
(5) Antibodies against diphtheria, smallpox, scarlet fever, measles, etc. pass from maternal blood to foetal blood through placenta and provide passive immunity.
(6) It stores the glycogen till the formation of liver.
(7) Though the placenta acts as an effective barrier for certain toxic chemicals like histamine but certain germs like AIDS virus, syphilis bacteria, viruses of German measles, etc, intoxicants like nicotine of cigarette smoke; and addictive drugs like heroin and cocaine can pass through the placenta and cause the developmental defects.

Placenta and disease

(1) Viral and bacterial infections of placenta are known as placentitis.
(2) If the mother suffer from certain diseases like syphilis, smallpox, chickenpox, AIDS and measles; their pathogen enter into the foetus through placenta.
(3) Many drugs used medicinally may penetrate the placental barriers.
(4) Drugs such as thalidomide taken as a sedative by woman in early pregnancy (25 to 44 days) cause extensive deficiencies in the development of limbs, the alimentary canal (non perforation of the anus) and the heart in children.
(5) Nicotine from cigarette smoke crosses the placenta and stunts foetal growth.
(6) Addictive drugs such as heroin and cocaine reach the foetus, causing addiction to the new born.

Classification of placenta

According to the foetal membrane involved in the formation of placenta.
(1) Yolk sac placenta : In metatheria or marsupials, such as kangaroo (macropus) and opossum (Didelphys), placenta is derived from yolk sac and chorion. In metatheria, yolk sac placenta is only weakly developed so that embryonic nutrition and growth remain limited and the young is born very small and immature. To compensate the deficiency of intrauterine development, it is transferred to the abdominal pouch or marsupium and fed on milk until fully formed. In higher mammals (Eutheria) a yolk sac placenta is usually not found but in some mammals (Hedgehogs and rabbit) it may be temporarily develop in early stages.
(2) Allantoic placenta : In the majority of Eutherian, the chief organ of embryonic nutrition is the allantoic placenta consist of allantois and chorion and also called allantochorionic placenta. Outside Eutharia, a primitive allantoic placenta occurs only in perameles (bandicoot) which is a metatherian.
(3) Chorionic placenta : It occurs in primates (man and apes) and is formed only by chorion. Allantois remains small, burrows into body stalk (umbilical cord) and does not reach chorion. However, its mesoderm and blood vessels grow upto chorion whose villi enter the uterine crypts forming chorionic placenta.

Pregnancy

Pregnancy, also known as gravidity or gestation, is the time during which one or more offspring develops inside a woman.[1] A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy can occur by sexual intercourse or assisted reproductive technology. It usually lasts around 40 weeks from the last menstrual period (LMP) and ends in childbirth.This is just over nine lunar months, where each month is about 29½ days. When measured from conception it is about 38 weeks. An embryo is the developing offspring during the first eight weeks following conception, after which, the term fetus is used until birth. Symptoms of early pregnancy may include missed periods, tender breasts, nausea and vomiting, hunger, and frequent urination. Pregnancy may be confirmed with a pregnancy test.
Pregnancy is typically divided into three trimesters. The first trimester is from week one through 12 and includes conception. Conception is when the sperm fertilizes the egg. The fertilized egg then travels down the fallopian tube and attaches to the inside of the uterus, where it begins to form the fetus and placenta. The first trimester carries the highest risk of miscarriage (natural death of embryo or fetus). The second trimester is from week 13 through 28. Around the middle of the second trimester, movement of the fetus may be felt. At 28 weeks, more than 90% of babies can survive outside of the uterus if provided high-quality medical care. The third trimester is from 29 weeks through 40 weeks.
Prenatal care improves pregnancy outcomes. Prenatal care may include taking extra folic acid, avoiding drugs and alcohol, regular exercise, blood tests, and regular physical examinations. Complications of pregnancy may include high blood pressure of pregnancy, gestational diabetes, iron-deficiency anemia, and severe nausea and vomiting among others. Term pregnancy is 37 to 41 weeks, with early term being 37 and 38 weeks, full term 39 and 40 weeks, and late term 41 weeks. After 41 weeks, it is known as post term. Babies born before 37 weeks are preterm and are at higher risk of health problems such as cerebral palsy. Delivery before 39 weeks by labor induction or caesarean section is not recommended unless required for other medical reasons.